If you struggle with attention and focus, want greater mental clarity, more physical energy, and crave a more positive outlook, then you could be one of many very smart people looking into using nootropics.
Sunifiram (which has the research chemical label D-235) is a newer smart drug. However, its roots are strongly linked to a couple of classes of nootropics that have existed since the 1960s.
So in this review, we are going to look into it in detail, telling you its positive effects, the sort of sunifiram dosage you should be using, and potential side effects to watch out for.
Plus, we will tell you how it stacks up Vs adderall, and tell you where you can buy sunifiram that’s pure and great to experiment with safely.
Sunifiram History & Pharmacology
Sunifiram (research candidate chemical label DM-235) , also known by its chemical structure of 1-benzoyl-propanoylpiperazine, is a more modern nootropic, developed in this century around the year 2000.
Although it’s structurally related to piracetam it is far more potent, 1000 times more potent, and has a slightly different mechanism of action, in addition to slightly different effects.
Sunifiram also has a close relative, called unifiram (DM-232). It has a slightly different structure and mechanism of action but works to produce its results in almost exactly the same way. Piracetam mimics the action of the inhibitory neurotransmitter GABA, an amino acid that helps to calm the central nervous system and overreactions by other neurotransmitters.
However, sunifiram is often mislabeled as a racetam. It’s not in that class at all, and it doesn’t interact with GABA at all. Sunifiram is actually thought to be a partial AMPA agonist, making it an Ampakine compound. This is a group of chemicals in the brain that helps to facilitate the transmission of nerve impulses.
It works by binding to glutamate and increasing its activity. Glutamate is a neurotransmitter and is most strongly linked with excitatory signals, activity in our brain that drives the central nervous system in several ways.
However, it’s important to note that no proper human studies have ever been completed, and most studies just relate to animals. On top of that, it’s a mechanism of action, how exactly sunifiram produces its results, is still poorly understood.
Because it is thought to be an AMPA agonist that increases the activity of glutamate through increasing its bioavailability, sunifiram can produce a very specific set of effects:
- Better mental clarity and performance
- Stronger memory formation
- Faster memory recall
- Enhanced perception
- Increased sex drive
- Can potentially reverse memory loss
- Improved mood
- Acts as a mild physical stimulant
So overall, effects are very similar to those of modafinil, which is why it is often compared to that nootropic. However, it doesn’t have the potential negative side effects of modafinil which can cause people problems, especially skin rashes and potential for a serious skin condition (although the chances are very small).
Using sunifiram will deliver better cognitive performance for several hours on one dose. You’ll think better, faster, and be able to cope with more. You’ll have more energy, a more positive outlook, and come across as far more engaged and perceptive.
Dosage That Worked For Me
Because it’s so potent, you don’t need a large dose of sunifiram. In fact, most negative side effects come from taking a dosage that is far too high. Beginner dose should be around 5 mg, and 8 mg is typical. At 10 mg and higher things start to get overwhelming and adverse side effects can kick in.
If you’re starting out with dosing it then you should be considering a dose of less than 5 mg the first time out. If you’re looking to experience a sunifiram high, which is possible at high doses, giving you a buzz and sense of flying while remaining in a cognitive heaven, then you are looking at doses above 10 mg.
But trying to achieve a sunifiram high could be problematic if you are doing it too frequently, as could dosing this smart drug too often, as this is when side effects and problems can kick in.
Sunifiram Vs Adderall
At doses of 10 mg and above sunifiram is often compared to adderall. Both can act as stimulants that bring improved cognitive performance. Both improve attention span, communication, problems solving skills, creativity improvements, and enhance memory function.
However, adderall works like amphetamine, which makes it a strong central nervous system stimulant in a way that incomparable to sunifiram.
Adderall provokes more release and less reuptake of dopamine and norepinephrine to produce its mental and physical effects. This produces stronger physical responses than you will get using sunifiram.
Possible Side Effects (That I Didn’t Experience)
At low doses, and with intermittent sensible use, side effects should be minimal, or even non-existent.
With intermittent use, by which we mean a couple of times per week at a moderate dose, you should not have any problems. But if you start increasing the dose and frequency, then you are at risk of developing side effects:
- Physical jitters
But there is one more potentially serious side effect that you need to be aware of because sunifiram works by massively increased levels of glutamate.
Glutamate excites cells to produce its results in the body. But continual over-excitement can damage or kill those cells. That’s why glutamate at high doses is known as an excitotoxin. So to avoid the potential for cellular damage, you should not use it at high doses, or too frequently.
However, it’s important to note that the risk is low, and it’s mainly linked to people who have an over-sensitivity to glutamate, which is what people at risk from Huntington’s disease inherently have.
Where To Buy Nootropics Online
So the conclusion of this sunifiram review is that it’s a potent nootropic with potentially significant cognitive benefits. However, you have to treat it with respect in terms of dosage and frequency.
It’s possible to use it to get a sunifiram high, but it’s not recommended to do that frequently because you put yourself at risk of an increased chance of cellular damage. But if you stick to a reasonable dosage, you shouldn’t have any problems.
So if you’re looking to buy sunifiram and experiment with it, the best place we’ve found to recommend you get it from is a highly professional company called Science.bio. They sell a huge range of supplements at fantastic prices. All of their supplements are also independently batch lab tested for purity and quality guaranteed.